Related Experiment Video
Updated: Sep 27, 2026

An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
Nodular hyperplasia, black thyroid, and chronic minocycline ingestion in a teenager
D L Folsom1, M W Gauderer, W T Dahms
1Department of Surgery, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Abstract:
An 18-year-old man with left-lobe thyroid hemiagenesis underwent isthmectomy for management of a nodule that failed to take up radioactive iodine during a nuclear scan. The resected tissue, which demonstrated nodular hyperplasia, and the remaining right lobe, were black. The association between deep staining and chronic minocycline ingestion was subsequently recognized. Twelve years later, the patient remained asymptomatic, suggesting that complete resection of tetracycline-stained thyroid tissue is unnecessary.
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