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[Contraception using a subcutaneous implant, Norplant].

M Vekemans¹, B Tissot

¹Service de Gynécologie-Obstétrique, Hôpital Universitaire Saint-Pierre, Bruxelles.

Revue Medicale De Bruxelles

|October 1, 1992

Summary

Norplant, a 5-year contraceptive implant releasing levonorgestrel, demonstrated high effectiveness with a Pearl Index of 0.46. The study found menstrual disturbances were the main side effect, with no absolute contraindications.

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Area of Science:

Reproductive Medicine
Contraception
Pharmacology

Context:

Prospective study of Norplant contraceptive device in 198 women in Belgium.
Total follow-up of 2,643 patient-months over 42 months.
Norplant is a subdermal implant releasing levonorgestrel for long-term contraception.

Purpose:

To evaluate the efficacy and side effects of Norplant as a contraceptive method.
To determine the Pearl Index and continuity rates for Norplant.
To identify contraindications and safety profile of Norplant.

Summary:

Norplant, a six-capsule implant releasing levonorgestrel, provides 5 years of pregnancy protection.
The study reported a low Pearl Index of 0.46% women-years, with only one pregnancy.

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High continuity rates were observed: 86% after 1 year and 60% after 2 years.

Main side effects included menstrual disturbances and abnormal bleeding; no significant adverse events were noted.

Impact:

Norplant offers a highly effective, long-term reversible contraceptive option.
The findings support Norplant's safety profile, with no absolute contraindications identified.
This study provides valuable data for the potential commercialization and clinical use of Norplant.