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What have tissue culture studies told us about the development of oligodendrocytes?
1National Institute for Medical Research, Mill Hill, London, UK.
Abstract:
One major success of studying neural cell development in tissue culture has been the discovery of the O-2A cell. This bipotential cell generates oligodendrocytes or, under certain conditions, a type of astrocyte. This essay considers the evidence that the characteristic properties demonstrated by the O-2A cells in vitro are an accurate reflection of oligodendrocyte development in vivo.