Related Experiment Videos
[Complement (C3 and C4) in patients with rheumatoid arthritis during 6 months of treatment with gold salts]
1Klinika za fizikalnu medicinu, rehabilitaciju i reumatologiju, Medicinskog fakulteta u KB Sestre milosrdnice, Zagreb.
Insights
Gold-salts like "Tauredon" significantly increase complement C3 levels in rheumatoid arthritis patients. However, "Tauredon" did not show a significant effect on complement C4 levels during the 6-month study.
Area of Science:
- Immunology
- Rheumatology
- Pharmacology
Context:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease.
- Complement system plays a role in RA pathogenesis.
- Gold salts have been used in RA treatment.
Purpose:
- To investigate the effect of gold salt
- Tauredon
- on complement C3 and C4 levels in RA patients.
Summary:
- This 6-month study observed 43 RA patients (8 males, 35 females, average age 50).
- Treatment with
- Tauredon
- led to a significant increase in serum C3 levels (P = 0.006).
- No significant effect was observed on complement C4 levels (P = 0.117).
Impact:
- Findings suggest
- Tauredon
- may modulate the complement system in RA.
- This could offer insights into the therapeutic mechanisms of gold salts in RA.
- Further research is needed to explore the clinical implications of C3 level changes.
Abstract:
The aim of research was to establish effect of gold-salts under protected name "Tauredon" Byk Gulden, on the dynamics of fraction of complements C3 and C4 at patients with rheumatoid arthritis. Following the dynamics of both parameters, was performed during 6 months continued application of "Tauredon", on 8 men and 35 women with certain diagnosis. Profile of the age of patients was 50 years old. With continuous observation of patients and their laboratory findings, in regular time intervals, we found out that "Tauredon" has significant influence on increase of level of C3 in serum of patients (P = 0.006) but not in increase of fraction of complement C4 (P = 0.117).