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Alginate as immobilization matrix for cells.

O Smidsrød1, G Skjåk-Braek

  • 1Division of Biotechnology, Norwegian Institute of Technology, Trondheim.

Trends in Biotechnology
|March 1, 1990
PubMed
Summary

Cell immobilization using calcium alginate spheres is a versatile technique with broad applications. This review examines the structural and functional properties of alginate gels for cell entrapment.

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Area of Science:

  • Biotechnology
  • Materials Science
  • Cell Biology

Background:

  • Cell immobilization is crucial for various biotechnological applications.
  • Calcium alginate spheres offer a widely adopted method for cell entrapment.
  • This technique supports diverse applications including bioreactors, micropropagation, and artificial organs.

Purpose of the Study:

  • To review the potential of calcium alginate for cell immobilization.
  • To evaluate the method based on current knowledge of alginate gel properties.

Main Methods:

  • Literature review focusing on structural and functional aspects of alginate gels.
  • Analysis of existing research on cell entrapment in calcium alginate.

Main Results:

  • Calcium alginate entrapment is a versatile and established technique.
  • The method's success is linked to the structural and functional characteristics of the alginate matrix.

Conclusions:

  • Calcium alginate immobilization holds significant potential across various biological applications.
  • Further understanding of structure-function relationships can optimize cell entrapment strategies.

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