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Antibody geometry and form: three-dimensional relationships between anti-idiotypic antibodies and external antigens

W V Williams1, D B Weiner, T Kieber-Emmons

  • 1Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104-4283.

Trends in Biotechnology
|September 1, 1990
PubMed

Anti-idiotypes have been developed to mimic a wide variety of antigens in studies of antibody-antigen interactions. Molecular, biochemical and structural analysis of antibody-anti-idiotype pairs presents an excellent model for study of complex protein-protein interactions. An understanding of the ways in which anti-idiotypes mimic antigens and the features determining binding characteristics will facilitate rational design of compounds with biological, enzymatic, pharmaceutical and chemical applications.

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