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Updated: Aug 9, 2026

Stem-cell Based Engineered Immunity Against HIV Infection in the Humanized Mouse Model
Published on: July 2, 2016
CD4-targeted immune intervention: a strategy for the therapy of AIDS and autoimmune disease
C Auffray1, D Piatier-Tonneau, G Kroemer
1Institut d'Embryologie du CNRS Collège de France, Nogent-sur-Marne.
Abstract:
The cell-surface antigen CD4 plays a pivotal role in the class II MHC-restricted response of specific T lymphocytes, and serves as the major receptor of human immunodeficiency virus (HIV). The recent elucidation of CD4 function in physiological and pathological conditions has improved prospects for CD4-targeted immune therapy by facilitating the design of therapeutic strategies aimed at blocking CD4 function, delivering immunosuppressive signals via this receptor molecule, or selectively depleting CD4+ cells.
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