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Strain improvement of Penicillium chrysogenum by recombinant DNA techniques
A E Veenstra1, P van Solingen, R A Bovenberg
1Gist-brocades Research and Development, Delft, The Netherlands.
Journal of Biotechnology
|January 1, 1991
Abstract:
The penDE gene from Penicillium chrysogenum has been isolated; the gene is located in close vicinity of the pcbC gene. Amplification of the pcbC-penDE gene cluster in Penicillium chrysogenum Wis54-1255 leads to a significant increase in penicillin production. In selected transformants an increase of up to 40% is observed.