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An analysis of some batch and continuous kinetic data of specific monoclonal antibody production from hybridomas
P J Phillips1, C P Marquis, J P Barford
1Department of Chemical Engineering, University of Sydney, NSW, Australia.
Abstract:
An analysis of batch and continuous kinetic data obtained from hybridoma cell cultures has been performed with particular reference to the existence of specific antibody production profiles. The results presented by several groups, including our own, have been studied. Our analysis suggests that different interpretations of the data can be made to those previously presented in the literature. In view of the significance of these profiles, particularly in terms of production strategies designed to maximise antibody production, we believe that more consideration needs to be given to accuracy in reporting of kinetic studies in the future.