Related Experiment Video
Updated: Jul 2, 2026

Study Motor Skill Learning by Single-pellet Reaching Tasks in Mice
Published on: March 5, 2014
[Augmentation of cholinergic activity of the neostriatum alters established type of motor behaviour in animals]
1Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Abstract:
Bilateral microinjections of carbacholine into dorsolateral portion of the caudate nucleus head reduced a phasic component, augmented a tonic component of instrumental response, inhibited interstimuluv raisings, normalised posture, and calmed down the dogs under study. They also improved differentiation of meaningful signals. Microinjections of scopolamine into the striatum induced opposite effects. Bilateral injections provided a longer lasting effect on both motor and sensory components of instrumental responses.
Related Concept Videos
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Direct-Acting Cholinergic Agonists: Pharmacological Actions
Indirect-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
Reversible inhibitors display short to medium durations of action. Short-acting agents include simple alcohols with...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
Indirect-Acting Cholinergic Agonists: Pharmacological Actions
At the neuromuscular junction, these agents work by inhibiting the breakdown of acetylcholine, allowing it to remain bound to the receptor and bind to nearby receptors. This process leads to repetitive firing of the endplate, causing muscle...
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...

