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Pregnancy-associated thrombosis.

Ingrid Pabinger1, Helga Grafenhofer

  • 1Division of Haematology and Blood Coagulation, Department of Internal Medicine I, University Hospital, Vienna, Austria. ingrid.pabinger@akh-wien.ac.at

Wiener Klinische Wochenschrift
|September 19, 2003
PubMed
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Pregnancy significantly increases venous thromboembolism (VTE) risk, especially postpartum. Objective diagnosis and heparin anticoagulation are crucial for managing VTE during pregnancy and the puerperium.

Area of Science:

  • Obstetrics and Gynecology
  • Hematology
  • Thrombosis Research

Background:

  • Venous thromboembolism (VTE) is a major cause of maternal morbidity and mortality.
  • Pregnancy elevates VTE risk fivefold, with postpartum presenting even higher risks.
  • Certain inherited thrombophilias and antiphospholipid antibodies further increase VTE susceptibility.

Purpose of the Study:

  • To summarize the risks and management of pregnancy-associated venous thromboembolism (VTE).
  • To highlight diagnostic challenges and treatment strategies for VTE in pregnant and postpartum women.

Main Methods:

  • Review of existing literature on pregnancy-associated VTE.
  • Analysis of risk factors including hereditary thrombophilias and antiphospholipid antibodies.

Related Experiment Videos

  • Discussion of diagnostic modalities and treatment with anticoagulants like heparin.

    • Main Results:

    • Pregnancy associated VTE incidence is approximately 1 in 1500 deliveries.
    • Hereditary risk factors can increase VTE risk by 3.4 to 15.2 fold.
    • Heparin is the preferred anticoagulant as it does not cross the placenta.

    Conclusions:

    • Objective diagnosis is essential for VTE management during pregnancy.
    • Prophylactic heparin is recommended for high-risk pregnancies and postpartum periods.
    • Management strategies should be individualized based on patient history and risk factors.