Lipid and lipoprotein testing in resource-limited laboratories

Area of Science:

• Clinical Chemistry
• Public Health Laboratory Science
• Cardiovascular Disease Risk Assessment

Background:

• Total cholesterol (TC) and lipoproteins, including low-density lipoprotein cholesterol (LDLC) and high-density lipoprotein cholesterol (HDLC), are established markers for coronary heart disease (CHD) risk.
• Increased lipid testing necessitates highly reliable laboratory results for effective CHD risk identification and management.
• Laboratories in resource-limited settings face significant challenges in establishing and maintaining lipid and lipoprotein testing capabilities.

Purpose of the Study:

• To highlight the importance of quality laboratory services in CHD prevention strategies.
• To address the challenges faced by laboratories with limited resources in implementing lipid and lipoprotein testing.
• To introduce the technical assistance provided by the Centers for Disease Control and Prevention (CDC) to support CHD public health programs in underserved areas.

Main Methods:

• The CDC provides technical assistance to laboratories aiming to develop lipid and lipoprotein testing.
• Assistance includes guidance on selecting appropriate testing instruments.
• Training for laboratory technicians, development of quality control plans, and preparation of control materials are key components of the support.

Main Results:

• The CDC has over 30 years of experience in providing technical assistance for lipid and lipoprotein testing.
• The CDC is committed to offering ongoing support to laboratories needing to establish or improve this capability.
• This assistance aims to ensure the accuracy and reliability of CHD risk marker measurements in diverse laboratory settings.

Conclusions:

• Quality laboratory services are essential for effective coronary heart disease risk assessment and reduction.
• The CDC's technical assistance program is vital for enabling laboratories with limited resources to perform accurate lipid and lipoprotein testing.
• Supporting laboratory capability is a critical component of public health strategies to combat cardiovascular disease globally.