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Antimicrobial activity of some Hypericum species
R Dall'Agnol1, A Ferraz, A P Bernardi
1Programa de Pós Graduação em Ciências Farmacêuticas, UFRGS, Porto Alegre, RS, Brazil.
Phytomedicine : International Journal of Phytotherapy and Phytopharmacology
|September 19, 2003
Summary
Six Hypericum species from Brazil were screened for antimicrobial properties. H. caprifoliatum showed activity against Staphylococcus aureus, while H. polyanthemum and H. ternum were active against Bacillus subtilis.
Area of Science:
- Phytochemistry
- Microbiology
- Pharmacognosy
Background:
- The genus Hypericum is known for its medicinal properties.
- Several Hypericum species are used in traditional medicine.
- Investigating the antimicrobial potential of lesser-known Hypericum species is important.
Purpose of the Study:
- To evaluate the antimicrobial activity of six Hypericum species from southern Brazil.
- To identify the main chemical constituents responsible for the observed activity.
Main Methods:
- Crude methanolic extracts of six Hypericum species were prepared.
- Antimicrobial activity was tested against various bacteria and fungi.
- Phytochemical analysis was performed to identify prominent compounds.
Main Results:
- Hypericum caprifoliatum extract showed significant activity against Staphylococcus aureus.
- Hypericum polyanthemum and H. ternum extracts were active against Bacillus subtilis.
- No extracts were effective against S. epidermidis, Escherichia coli, or Saccharomyces cerevisiae.
- Tannins, flavonoids, and phenolic acids were the predominant compounds. Quercitrin and hyperoside were commonly found.
Conclusions:
- Hypericum caprifoliatum, H. polyanthemum, and H. ternum possess antimicrobial properties against specific bacteria.
- The presence of tannins and flavonoids contributes to the antimicrobial activity.
- Further research into these species could yield new antimicrobial agents.