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Flavonol glycosides from Monnina sylvatica.

A Bashir1, M Hamburger, M P Gupta

  • 1Institut de Pharmacognosie et Phytochimie, Ecole de Pharmacie, Université de Lausanne, Switzerland.

Phytochemistry
|January 1, 1991
PubMed
Summary

Researchers isolated a new kaempferol triglycoside and three known kaempferol glycosides from Monnina sylvatica. Structural analysis confirmed a novel natural product, expanding knowledge of plant-derived flavonoids.

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Area of Science:

  • Phytochemistry
  • Natural Products Chemistry
  • Organic Chemistry

Background:

  • Monnina sylvatica is a plant species known for its potential bioactive compounds.
  • Flavonoids, particularly kaempferol glycosides, are widely studied for their diverse biological activities.
  • Isolation and characterization of novel natural products contribute to understanding plant chemical diversity.

Purpose of the Study:

  • To isolate and elucidate the structures of compounds from the aerial parts of Monnina sylvatica.
  • To identify new natural products and characterize known kaempferol glycosides.
  • To contribute to the phytochemical knowledge of the Monnina genus.

Main Methods:

  • Isolation of compounds using chromatographic techniques.
  • Structural elucidation employing acid and enzymatic hydrolysis.

Related Experiment Videos

  • Spectroscopic analyses including UV, 1H and 13C NMR, NOE difference measurements, and mass spectrometry (D/CI and FAB-MS).
  • Main Results:

    • A new kaempferol triglycoside, kaempferol 3-O-beta-D-glucosyl-(1----2)-O-[alpha-L-rhamnosyl(1----6)]-beta-D-galactoside, was identified.
    • Three known kaempferol glycosides, including two apiosides, were isolated and characterized.
    • The configuration of the apiosyl moiety in specific galactosides was determined using NOE difference measurements on peracetate derivatives.

    Conclusions:

    • The study successfully identified and characterized a novel kaempferol triglycoside from Monnina sylvatica.
    • The findings expand the repertoire of known kaempferol glycosides and provide detailed structural information.
    • This research enhances the understanding of the chemical constituents of Monnina sylvatica and contributes to natural product chemistry.