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Related Experiment Videos

Evolution of segmentation: rolling back the clock.

Andrew Peel1, Michael Akam

  • 1Laboratory for Development and Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK.

Current Biology : CB
|September 19, 2003
PubMed
Summary
This summary is machine-generated.

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Similarities in genetic mechanisms for somitogenesis in zebrafish and spider segmentation suggest the bilaterian ancestor may have been segmented. This finding offers new insights into early animal evolution.

Area of Science:

  • Developmental Biology
  • Evolutionary Biology
  • Genetics

Background:

  • Recent research highlights conserved genetic pathways in animal development.
  • Somitogenesis in zebrafish and arthropod segmentation share molecular underpinnings.

Purpose of the Study:

  • To investigate the evolutionary implications of conserved segmentation mechanisms.
  • To explore the possibility of segmentation in the bilaterian common ancestor.

Main Methods:

  • Comparative genomics analysis.
  • Molecular pathway analysis in zebrafish and spider models.

Main Results:

  • Striking similarities were found in the genetic control of somitogenesis and segmentation.
  • These conserved mechanisms suggest a deep evolutionary origin of segmentation.

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Conclusions:

  • The findings support the hypothesis that the bilaterian common ancestor was segmented.
  • This provides a new perspective on the evolution of body plan organization in animals.