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Related Experiment Videos

Antisense technology.

S T Crooke1

  • 1ISIS Pharmaceuticals, Carlsbad, California.

Current Opinion in Biotechnology
|April 1, 1991
PubMed
Summary
This summary is machine-generated.

Recent medicinal chemistry advances offer substantial potential for developing novel oligonucleotide therapeutics. Enhanced understanding of oligonucleotide pharmacodynamics and pharmacokinetics supports their use against diverse molecular targets.

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Area of Science:

  • Medicinal Chemistry
  • Pharmacology
  • Drug Development

Background:

  • Oligonucleotides are a promising class of therapeutic agents.
  • Recent research has focused on improving their medicinal chemistry and understanding their biological behavior.

Purpose of the Study:

  • To review recent advances in oligonucleotide medicinal chemistry.
  • To highlight the progress in understanding oligonucleotide pharmacodynamics and pharmacokinetics.
  • To underscore the therapeutic potential of modified oligonucleotides.

Main Methods:

  • Review of recent scientific literature on oligonucleotide development.
  • Analysis of medicinal chemistry modifications.
  • Evaluation of pharmacodynamic and pharmacokinetic data.

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Main Results:

  • Significant advances in oligonucleotide medicinal chemistry have been reported.
  • A clearer understanding of oligonucleotide pharmacodynamic and pharmacokinetic properties has been achieved.
  • Oligonucleotides have demonstrated activity against an increasing number of molecular targets.

Conclusions:

  • The scope for developing novel therapeutic agents through oligonucleotide modifications is substantial.
  • Improved understanding of oligonucleotide properties supports their therapeutic application.
  • Oligonucleotides represent a rapidly advancing field with significant therapeutic promise.