Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ibuprofen quality control by electrochromatography.

M G Quaglia1, E Donati, S Fanali

  • 1Dipartimento Studi Farmaceutici, Università La Sapienza, P.le A. Moro 5, 00185 Rome, Italy. mariagiovanna.quaglia@uniroma1.it

Farmaco (Societa Chimica Italiana : 1989)
|September 19, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Toxic response of the bacterium Vibrio fischeri to sodium lauryl ether sulphate residues in excavated soils.

Ecotoxicology (London, England)·2020
Same author

Instant loading with intraoral welding technique and PRAMA implants: a new prosthetic approach.

Journal of biological regulators and homeostatic agents·2017
Same author

Biomechanical considerations on macromorphology of endosseous dental implants.

Journal of biological regulators and homeostatic agents·2017
Same author

Static and fatigue resistance of two types of implant/abutment connectors.

Journal of biological regulators and homeostatic agents·2017
Same author

Response of Lemna gibba L. to high and environmentally relevant concentrations of ibuprofen: Removal, metabolism and morpho-physiological traits for biomonitoring of emerging contaminants.

The Science of the total environment·2017
Same author

The inhalation toxicity of perchloryl fluoride.

Technical report. CRDLR. US Army Edgewood Arsenal Chemical Research and Development Laboratories·2014

Capillary electrochromatography (CEC) offers an alternative to HPLC for drug quality control. This study demonstrates CEC

Area of Science:

  • Analytical Chemistry
  • Separation Science
  • Pharmaceutical Analysis

Background:

  • High-Performance Liquid Chromatography (HPLC) is the standard for drug quality control.
  • Capillary Electrochromatography (CEC) presents a viable alternative for pharmaceutical analysis.
  • Analyzing non-steroidal anti-inflammatory drugs (NSAIDs) and their impurities is crucial for quality assurance.

Purpose of the Study:

  • To investigate the application of CEC for the analysis of ibuprofen and its impurities.
  • To optimize CEC parameters for effective separation of ibuprofen from related compounds.
  • To evaluate the selectivity and efficiency of CEC for pharmaceutical quality control.

Main Methods:

  • Capillary electrochromatography (CEC) using a fused silica capillary (100-microm inner diameter).

Related Experiment Videos

  • RP-18 stationary phase packed within the capillary.
  • Mobile phase composition: formic acid solution (100 mM, pH 2.5), water, and acetonitrile (ACN).
  • Optimization of ACN percentage and applied voltage for enhanced resolution.

    • Main Results:

    • Successful separation of ibuprofen from its impurities using CEC.
    • Demonstrated high selectivity and efficiency of the CEC method.
    • Identified optimal mobile phase composition and voltage for resolving ibuprofen and related compounds.

    Conclusions:

    • CEC is an effective technique for the quality control of ibuprofen.
    • The developed CEC method offers superior selectivity and efficiency compared to traditional methods.
    • CEC provides a promising alternative for the analysis of pharmaceuticals and their impurities.