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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Synthesis and affinity for serotonin and dopamine transporters of some benzophenone oxime ether derivatives
Annalina Lapucci1, Susanna Nencetti, Gian Carlo Demontis
1Dipartimento di Scienze Farmaceutiche, Facoltà di Farmacia, Università di Pisa, Via Bonanno 6, 56100 Pisa, Italy. alapucci@farm.unipi.it
Abstract:
In a previous study, we reported the synthesis of several 3-(methylenaminoxymethyl)-substituted piperidine derivatives and their ability to interfere with the transmission mediated by biogenic amines. The present study describes the preparation of some new oxime derivatives and their capacity to inhibit serotonin (SERT) and dopamine (DAT) transporters expressed at the level of the rabbit cortex and the striatal membranes, respectively. All the compounds showed K(i) values in the micromolar range on both transporters.
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