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1,2-dithiolan-3-ones and derivatives structurally related to leinamycin. Synthesis and biological evaluation
Raul Salvetti1, Giovanni Martinetti, Daniela Ubiali
1Dipartimento di Chimica Farmaceutica, Università degli Studi di Pavia, via Taramelli 12, I- 27100 Pavia, Italy.
Farmaco (Societa Chimica Italiana : 1989)
|September 19, 2003
Abstract:
Leinamycin, an antitumor antibiotic isolated from Streptomyces sp., shows a 1,2-dithiolan-3-one 1-oxide heterocycle that appears to be involved in the biological activity. Several derivatives related to 1,2-dithiolan-3-one 1-oxide have been prepared and their activity as antineoplastic agents have been investigated. The synthesized compounds did not display a significative antitumor or cytotoxic activity in vitro.