Laser immunotherapy: a novel treatment modality for metastatic tumors
Related Experiment Video
Updated: Sep 13, 2026

An Immunocompetent Murine Model for Laser Interstitial Thermal Therapy of Glioblastoma
Published on: November 15, 2024
Wei R Chen1, Raoul Carubelli, Hong Liu
1Biomedical Engineering Program, Department of Physics and Engineering, University of Central Oklahoma, 100 N. University Drive, Edmond, OK 73034, USA. wchen@ucok.edu
Abstract:
Laser immunotherapy is a novel approach for the treatment of metastatic tumors. It combines a selective photothermal laser-tissue interaction for direct tumor destruction and an immunoadjuvant-directed simulation for immune responses. In experiments using a rat metastatic tumor model, laser immunotherapy resulted in the eradication of both treated primary tumors and untreated metastases at remote sites. It also induced anti-tumor resistance.
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