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Related Experiment Video

Updated: Jul 26, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

Value and limitation of meta-analysis.

¹Center for Molecular and Vascular Biology, University of Leuven, Campus Gasthuisberg, O & N, Herestraat 49, B-3000 Leuven, Belgium. marc.verstraete@med.kuleuven.ac.be

Pathophysiology of Haemostasis and Thrombosis

|September 19, 2003

Summary

Meta-analysis combines trial data for robust findings. Strict data selection and trial registration are vital to prevent publication bias and ensure valid results.

Area of Science:

Biostatistics
Clinical Research Methodology

Background:

Meta-analysis is a powerful tool for synthesizing evidence from multiple studies.
Ensuring the validity of meta-analyses requires rigorous data handling and adherence to established protocols.

Purpose of the Study:

To highlight the critical importance of data retrieval and selection in meta-analysis.
To address the issue of underreporting and publication bias in clinical trials.

Main Methods:

Emphasizes the necessity of a predefined protocol for meta-analysis.
Discusses the impact of non-adherence to protocols on study validity.

Main Results:

Many meta-analyses are compromised by flawed methodologies, including lack of protocols.

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The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials

The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials

Published on: April 19, 2024

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Last Updated: Jul 26, 2026

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Meta-analysis of Voxel-Based Neuroimaging Studies using Seed-based d Mapping with Permutation of Subject Images (SDM-PSI)

Published on: November 27, 2019

The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials

The Adjuvant Efficacy of Angong Niuhuang Pill in the Treatment of Viral Encephalitis: A Meta-Analysis of Randomized Controlled Trials

Published on: April 19, 2024

Underreporting of clinical trials, particularly those with negative outcomes, introduces significant bias.

Conclusions:

Publication bias, stemming from selective reporting of trial results, undermines meta-analysis.
Mandatory registration of all clinical trials in an international online database is proposed to mitigate bias.