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Determination of a "critical shear stress level" applied to adherent mammalian cells
A Ludwig1, G Kretzmer, K Schügerl
1Institut für Technische Chemie, Universität Hannover, FRG.
Enzyme and Microbial Technology
|March 1, 1992
Abstract:
An apparatus for the detailed investigation of the influence of shear stress on adherent BHK cells was developed. Shear forces between 0.0 and 2.5 N m-2 were studied. The influence on cell viability, cell morphology, cell lysis, and cell size was determined. Increasing shear forces as well as increasing exposure duration caused increasing changes in cell morphology and cell death. A "critical shear stress level" was determined.