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Screening for hemoglobin disorders in Thai pregnant women by England and Frazer's calculation method
Jamsai Suwansaksri1, Viroj Wiwanitkit, Nara Paritpokee
1Department of Clinical Chemistry, Faculty of Allied Health Science, Chulalongkorn University, 10330 Bangkok, Thailand. Jamsai.S@chula.ac.th
Objective:
Our objective was to perform a preliminary study screening for hemoglobin disorders among Thai pregnant women using England and Frazer's calculation method.
Patients:
One hundred and thirty-five pregnant women who receive antenatal laboratory check-up from the Out-Patient Division, King Chulalongkorn Memorial Hospital.
Methods:
Endocrine disruptor testing and assessment (EDTA) blood specimens from each patient were analyzed by two methods in order to screen for inherited hemoglobin disorders. Hemoglobin and genotype analysis was set as the confirmation method. Blood indices investigation performed by automated hematology analyzer was set for England and Frazer's calculation method as the screening method.
Results:
The sensitivity and specificity of the method using England and Frazer's calculation were 92.3 and 100%. False positive and false negative results were 0% and 7.7%.
Conclusion:
England and Frazer's calculation method can be an alternative method that can help screen for hemoglobin E disorders in pregnant women.
