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Determination of melagatran in rabbit plasma by high-performance liquid chromatography with automated column
Byoung-Hyoun Kim1, Sun Young Park, Nak Hee Choi
1Analytical and Computational Science, Research Park, LG Chemical Ltd, 104-1 Moonji-dong, Yusong-gu, Daejon 305-380, South Korea. bhkime@lgchem.com
Biomedical Chromatography : BMC
|September 19, 2003
Abstract:
Melagatran is an active thrombin inhibitor showing oral and parenteral bioavailability for antithrombotic therapy. A simple and convenient liquid chromatographic method has been developed and applied to the analysis of melagatran in rabbit plasma. The clean-up and separation of the sample solutions were performed by automated on-line column switching HPLC. The method validation shows the suitability of the column switching liquid chromatographic system for the quantitation of melagatran in biological fluids.