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Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Pharmacology of methicillin

P ACRED, D M BROWN, D H TURNER

    British Journal of Pharmacology and Chemotherapy
    |August 1, 1961
    PubMed

    Insights

    Methicillin, a new antibiotic effective against penicillin-resistant staphylococci, shows favorable pharmacology. It has minimal toxicity and similar serum/tissue concentrations to penicillin G after intramuscular injection.

    Area of Science:

    • Pharmacology
    • Microbiology
    • Drug Metabolism

    Background:

    • Penicillin G resistance in Staphylococcus is a growing clinical concern.
    • Development of novel antibiotics is crucial for combating resistant bacterial strains.

    Purpose of the Study:

    • To investigate the pharmacology of methicillin, a new antibiotic.
    • To assess methicillin's efficacy against penicillin-resistant staphylococci.

    Main Methods:

    • Pharmacological investigation of methicillin.
    • Assessment of toxicity, absorption, distribution, and excretion.
    • Metabolism studies.

    Main Results:

    • Methicillin is effective against penicillin G-resistant staphylococci.
    • It exhibits minimal acute and chronic toxicity, with minor injection site pain.
    • Oral absorption is poor, but intramuscular injection yields serum and tissue concentrations comparable to penicillin G.
    • Renal excretion occurs via tubular secretion and glomerular filtration.
    • Biliary excretion is high, with a bile-to-blood concentration ratio 2.5 times that of penicillin G.
    • Approximately 75% of methicillin is eliminated unchanged in urine; the remainder is likely degraded after biliary excretion.

    Conclusions:

    • Methicillin demonstrates a promising pharmacological profile for treating infections caused by penicillin-resistant staphylococci.
    • Its excretion pathways and metabolic fate are characterized, supporting its clinical utility.
    Keywords:
    PENICILLIN/pharmacology

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