Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Modeling transport processes in sterilization-in-place.

P T Noble1

  • 1Fluor Daniel GmbH, Wiesbaden, Germany.

Biotechnology Progress
|July 1, 1992
PubMed
Summary

Sterilization-in-place (SIP) using steam is improved by optimizing air and condensate removal. Reliable SIP design requires proper insulation, steam trap spacing, and high-quality steam for effective equipment sterilization.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of rotational flow stabilized continuous electrophoresis for protein fractionation.

Biotechnology progress·2010
Same author

Reduction of risk and the evaluation of quality assurance.

PDA journal of pharmaceutical science and technology·2001
Same author

Transport considerations for microbiological control in piping.

Journal of pharmaceutical science and technology : the official journal of PDA·1994
See all related articles

Area of Science:

  • Bioprocess Engineering
  • Sterilization Technology
  • Chemical Engineering

Background:

  • Sterilization-in-place (SIP) using saturated steam is crucial for aseptic processing.
  • Steam distribution is often limited by inefficient air and condensate removal during SIP cycles.
  • Optimizing these transport processes is key to enhancing SIP effectiveness.

Purpose of the Study:

  • To investigate the critical parameters affecting steam distribution during SIP.
  • To analyze the impact of air and condensate removal on sterilization efficacy.
  • To identify design improvements for more reliable and efficient SIP systems.

Main Methods:

  • Utilized simple model systems of pipes and tanks to study SIP processes.
  • Examined characteristic operating parameters and analyzed steady-state models.
  • Evaluated design aspects such as heat insulation, steam trap spacing, and line sloping.

Main Results:

  • Identified air removal prior to sterilization and condensate removal during sterilization as crucial operations.
  • Determined that effective air removal and condensate management significantly impact steam distribution.
  • Found that factors like heat insulation, steam trap placement, and steam quality are vital for reliable SIP.

Conclusions:

  • A more reliable SIP design is achievable through equipment insulation and strategic steam trap spacing.
  • Effective air removal operations and the provision of high-quality steam are essential for successful sterilization.
  • Optimized design parameters lead to improved steam distribution and enhanced sterilization efficacy.

Related Experiment Videos