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Flow injection analysis and in-line biosensors for bioprocess control: a comparison
H Lüdi1, M B Garn, S D Haemmerli
1CIBA-GEIGY AG, Analytical Research, Basel, Switzerland.
Journal of Biotechnology
|August 1, 1992
Summary
Miniaturization offers a unified approach for biosensors in bioprocess control. Flow injection analysis is identified as the optimal versatile system for integrating biosensors, paving the way for future miniaturized chemical analysis systems.
Area of Science:
- Biotechnology
- Analytical Chemistry
- Chemical Engineering
Background:
- Biosensors are crucial for monitoring bioprocesses.
- Current biosensor applications in bioprocess control lack unification.
- Miniaturization offers a path towards integrated analytical systems.
Purpose of the Study:
- To propose miniaturization as a unifying strategy for biosensor application in bioprocess control.
- To identify the most versatile system for introducing biosensors into bioprocess control.
- To highlight the potential of flow injection analysis in this context.
Main Methods:
- Conceptual analysis of biosensor integration strategies.
- Evaluation of different analytical systems for bioprocess control.
- Focus on flow injection analysis (FIA) as a versatile platform.
Main Results:
- Miniaturization is key to unifying diverse biosensor approaches.
- Flow injection analysis (FIA) is presented as the method of choice for biosensor integration.
- Significant experience will be gained for developing miniaturized total chemical analysis systems.
Conclusions:
- Miniaturization will standardize biosensor use in bioprocess control.
- Flow injection analysis (FIA) is the recommended versatile system for biosensor implementation.
- This approach facilitates advancements in miniaturized analytical systems.