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Immunologic studies of human plasma cells.

R Beaulieu, B Pirofsky, G H Davies

    American Journal of Hematology
    |January 1, 1976
    PubMed
    Summary

    This study investigated malignant plasma cells, finding neoplastic plasmablasts are denser than mature forms. These cells showed limited reactivity, suggesting a lymphoid origin, potentially linked to B-type lymphocytes.

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    Area of Science:

    • Immunology
    • Cell Biology
    • Hematology

    Background:

    • Plasma cells are crucial for antibody production.
    • Understanding malignant plasma cell properties is vital for disease management.

    Purpose of the Study:

    • To characterize the physical, biological, and immunological properties of malignant human plasma cells.
    • To elucidate the origin and relationships of plasma cells within the immune system.

    Main Methods:

    • Purification of plasma cell suspensions from subjects with malignant plasma cell disease.
    • Analysis of cell density, response to phytohemagglutinin, and mixed lymphocyte-plasma cell cultures.
    • Production and testing of antisera against plasma cells for cross-reactivity.

    Main Results:

    • Neoplastic human plasmablasts exhibited higher density compared to mature plasma cells.
    • Human plasma cells showed no response to phytohemagglutinin and weak reactivity in mixed cultures.
    • Generated antisera displayed broad cross-reactivity with human lymphocyte populations.

    Conclusions:

    • Data suggest a lymphoid origin for human plasma cells.
    • A potential specific relationship between plasma cells and B-type lymphocytes is indicated.

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