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Genetic engineering of beta-lactam antibiotic biosynthetic pathways in filamentous fungi
1Lilly Research Labs., Lilly Corporate Center, Indianapolis, IN 46285.
Trends in Biotechnology
|September 1, 1992
Abstract:
Recombinant DNA technology has facilitated a rapid increase in our knowledge of beta-lactam antibiotic biosynthesis. Using the tools of this technology, beta-lactam biosynthetic genes and proteins have been characterized at the molecular level, cephalosporin-C production has been improved, new beta-lactams produced, and novel beta-lactam biosynthetic pathways have been constructed.