Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Tissue engineering science: consequences of cell traction force.

R T Tranquillo1, M A Durrani, A G Moon

  • 1Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis 55455.

Cytotechnology
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Melanoma/CSPG4-Enhanced Collagen-Mediated Contact Guidance Requires Mutant Active BRAF and the CSPG4 Core Protein Cytoplasmic Domain.

Cellular and molecular bioengineering·2026
Same author

Magnetic-induced alignment of collagen fibrils in tissue equivalents.

Methods in molecular medicine·2011
Same author

Initial fiber alignment pattern alters extracellular matrix synthesis in fibroblast-populated fibrin gel cruciforms and correlates with predicted tension.

Annals of biomedical engineering·2010
Same author

Schwann cell behavior in three-dimensional collagen gels: evidence for differential mechano-transduction and the influence of TGF-beta 1 in morphological polarization and differentiation.

Experimental neurology·2005
Same author

Rational design of contact guiding, neurotrophic matrices for peripheral nerve regeneration.

Annals of biomedical engineering·2004
Same author

ECM gene expression correlates with in vitro tissue growth and development in fibrin gel remodeled by neonatal smooth muscle cells.

Matrix biology : journal of the International Society for Matrix Biology·2003
Same journal

Gamma-terpinene suppresses the growth of lymphoblastic cancerous cells in vitro<i>,</i> possibly via multiple proposed molecular mechanisms, including apoptosis and gene expression modulation.

Cytotechnology·2026
Same journal

USP5 inhibits osteogenic differentiation but promotes oxidative stress and M1-like macrophage polarization of human periodontal ligament stem cells via deubiquitinating and stabilizing RIPK1: insights from <i>in vitro</i> and <i>in vivo</i> analyses.

Cytotechnology·2026
Same journal

Combination of paclitaxel with eugenol effectively enhances anticancer characteristics of paclitaxel on the A549 lung cancer cell line.

Cytotechnology·2026
Same journal

RBM15 enhances ILDR1 n6-methyladenosine methylation to accelerate gastric adenocarcinoma progression via an IGF2BP3-dependent manner.

Cytotechnology·2026
Same journal

Apigenin attenuates hepatocyte senescence in metabolic dysfunction-associated steatotic liver disease by targeting the TGF-β signaling pathway.

Cytotechnology·2026
Same journal

Iodine-125 seed induces ferroptosis through inhibiting RNF216-mediated ubiquitination of p53 in cholangiocarcinoma cells.

Cytotechnology·2026
See all related articles

Cells exert traction forces on collagen networks, influencing cell migration and tissue mechanics. This interaction is crucial for understanding wound healing and designing bioartificial tissues, with mathematical models aiding in analysis.

Area of Science:

  • Biomedical Engineering
  • Biotechnology
  • Cell Biology
  • Tissue Mechanics

Background:

  • Cells mechanically interact with soft tissues and collagen gels.
  • Cell traction on collagen fibers is key to tissue integrity and cell behavior.
  • These interactions influence cell migration, tissue deformation, and cellular processes like DNA synthesis.

Purpose of the Study:

  • To describe mathematical theories for cell-tissue mechanical coupling.
  • To develop models for understanding wound healing and cell traction.
  • To analyze cell-collagen network interactions in biomedical contexts.

Main Methods:

  • Summarizing relevant mathematical theories.
  • Developing and applying mathematical models to cell-populated collagen gels.

Related Experiment Videos

  • Integrating cell biology and medical observations to critique models.

    • Main Results:

    • Cell traction can lead to coordinated cell migration and network deformation.
    • Network deformation can cause collagen fiber alignment, guiding cell movement.
    • Network stress and strain modulate cell synthesis and differentiation.

    Conclusions:

    • Cell-tissue mechanical coupling is a critical factor in biological processes.
    • Mathematical modeling provides insights into cell-driven tissue dynamics.
    • Understanding these interactions can inform wound healing therapies and bioartificial tissue design.