Types of mesenchymal reactions in the carcinoma of uterine cervix

In the cervical cancer stroma three essential types of mesenchymal reaction: myxoid, fibrogenic with angioplasia and fibroblastic low-differentiated were disclosed. The border membrane of cancer foci is composed of fibroblast layer and ground substance abundant in Ac-MPS of the hyaluronic acid type. This substance is the basal immunosuppressive factor of cancer cells in situ (TIS). Similar activity is exhibited by the pathologic mesenchymal proteins of fibrynoid and hyaline type. The level of chemical differentiation of the mesenchyma, changes according to the maturity of cellular factor in connective tissue. Ac-MPS of the hyaluronic acid type prevail in the ground substance of the myxoid and fibroblastic mesenchyma, while the substances containing sulfuric groups predominate in the tissue matrix exhibiting fibrogenic tendencies.