Elastoid transformation of the collagen fibrils in scleroderma skin

Electron microscope study was conducted on bioptic material taken from the skin of 20 scleroderma patients (15 with progressive scleroderma and five with circumscribed scleroderma). In all cases, we observed elastoid transformation of the collagen fibrils. This phenomenon has a focal character and can be formed either directly or indirectly. The direct elastoid transformation is a result of aggregation of superficially damaged collagen fibrils. In such cases the elastoid acquires a fibrous structure. The indirect elastoid transformation is preceded by the complete destruction of the collagen fibrils. The fibrous elastoid is considered to be a pathologic form of fibrogenesis in scleroderma.