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[Eosinophilia-myalgia: new syndrome].
1Oddział Chorób Wewnetrznych i Reumatologii Okregowego Szpitala Kolejowego, Wrocławiu.
Postepy Higieny I Medycyny Doswiadczalnej
|January 1, 1992
Summary
Eosinophilia-myalgia syndrome (EMS) shares similarities with toxic-oil syndrome, potentially linked to tryptophan. Chronic EMS involves long-term disability, skin thickening, neuropathy, and severe myalgias.
Area of Science:
- Toxicology
- Neurology
- Immunology
Background:
- Eosinophilia-myalgia syndrome (EMS) is a newly identified illness linked to tryptophan consumption.
- The toxic-oil syndrome in Spain (1981) presented similar clinical and histopathological features.
Purpose of the Study:
- To describe clinical, histopathological, and biochemical findings in EMS and toxic-oil syndrome patients.
- To investigate the potential factors contributing to EMS development.
Main Methods:
- Clinical case descriptions and histopathological examination of affected patients.
- Biochemical analyses of tryptophan metabolism.
- Comparison of findings between EMS and toxic-oil syndrome.
Main Results:
- Similarities observed in symptoms and laboratory findings between EMS and toxic-oil syndrome.
- Chronic EMS characterized by persistent disability, sclerodermatous skin changes, sensorimotor polyneuropathy, and severe myalgias.
- Tryptophan ingestion and activation of indoleamine-2,3-dioxygenase are implicated.
Conclusions:
- EMS and toxic-oil syndrome exhibit significant overlap in presentation.
- A multifactorial etiology for EMS is suggested, involving tryptophan, environmental factors, and potential HPA axis dysfunction.