Related Experiment Video
Updated: Aug 14, 2026

The Generation of Closed Femoral Fractures in Mice: A Model to Study Bone Healing
Published on: August 16, 2018
[Mineralization phenomena in the area of long bone fracture wound healing]
T Niedźwiedzki1, M Pawlikowski
1III Katedry Chirurgii AM w Krakowie.
Abstract:
Mineralization changes in the area of fracture healing in experimental rabbits were monitored during 28 days of observation. The changes were evaluated with the aid of microscopy in the polarized light, scanning microscopy, infrared spectroscopy and roentgenographic microanalysis in 7, 14, 21, and 28th day of healing process. Mineralization was found to be parallel to the increase of collagen quantity. In the course of healing an arrangement of atom structure of the phoshate takes place. Increasing mineralization is indicated not only by growing values of Ca and P in newly formed bone but also by Ca/P ratio approaching normal values in the final stage of healing. Despite of clinical and radiological features of bony union the process of mineralization is not yet completed. By the 28th day of healing the mineral structure of bone is still remarkably porous resembling cancellous bone. Cortical bone formation occurs on the basis of cancellous bone by organization of the osseous trabeculae.
Related Concept Videos
Bone Remodeling
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
The Bone Matrix
Fractures: Bone Repair
Minor fractures with no bone displacement are treated by immobilizing the fractured bone using a cast or splint. However, in the case of fractures with displaced bones, the broken bones are repositioned before immobilization to ensure successful healing without deformation and loss of function. The realignment of fractured bone ends is performed through a process called reduction. If the procedure...
Essential Minerals for Bone Health
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Bone Remodeling and Repair

