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Common principles in protein folding and antigen presentation
S Lu1, V E Reyes, R R Torgerson
1Department of Pharmacology, University of Massachusetts Medical School, Worcester 01655.
Trends in Biotechnology
|July 1, 1991
Abstract:
The regular recurrence of hydrophobic amino acid residues along a peptide sequence determines the formation of a longitudinal hydrophobic strip when the peptide forms an alpha-helix. An understanding of the ways this may affect both folding of nascent proteins and antigen presentation should facilitate vaccine and therapeutics design.