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Related Experiment Videos

A new brain glucosensor and its physiological significance.

Y Oomura1, K Sasaki, K Suzuki

  • 1Department of Higher Nervous Function Control Systems, Institute for Wakan-Yaku and Scientific Instrument Center, Toyama Medical and Pharmaceutical University, Japan.

The American Journal of Clinical Nutrition
|January 1, 1992
PubMed
Summary

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Fibroblast growth factor (FGF) in cerebrospinal fluid (CSF) suppresses feeding and enhances memory. Released by ependymal cells in response to glucose, FGF acts on brain neurons, offering neurotrophic benefits.

Area of Science:

  • Neuroscience
  • Endocrinology
  • Molecular Biology

Background:

  • Fibroblast growth factor (FGF) is present in cerebrospinal fluid (CSF).
  • Feeding behavior is influenced by factors within the central nervous system.

Purpose of the Study:

  • To investigate the role of FGF in regulating food intake and its effects on neuronal function.
  • To determine the source and regulation of FGF in the CSF.
  • To assess the neuroprotective and memory-enhancing properties of FGF.

Main Methods:

  • Measurement of FGF concentration in CSF after feeding.
  • Administration of FGF and anti-FGF antibody to assess effects on food intake.
  • In situ hybridization to identify FGF-producing cells.
  • Electrophysiological and behavioral studies to evaluate neuronal activity, neuroprotection, and memory.

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Main Results:

  • CSF FGF concentration increases post-feeding.
  • FGF administration suppressed food intake dose-dependently, while anti-FGF antibody facilitated it.
  • Acidic FGF (aFGF) is produced by ependymal cells and released in response to increased CSF glucose.
  • aFGF activates protein kinase C in glucose-sensitive lateral hypothalamic neurons.
  • aFGF infusion into CSF improved passive avoidance learning.
  • aFGF pretreatment protected hippocampal CA1 neurons from ischemic damage.

Conclusions:

  • aFGF is a potent regulator of feeding behavior.
  • aFGF acts as a neurotrophic factor, enhancing memory and providing neuroprotection against ischemia.
  • Ependymal cells play a key role in releasing aFGF into the CSF in response to metabolic cues.