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Studies on infection and immunity in experimental typhoid fever. III. Effect of prophylactic immunization

S GAINES, M LANDY, G EDSALL

    The Journal of Experimental Medicine
    |September 1, 1961
    PubMed

    A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa. It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection induced with either homologous or heterologous strains of typhoid bacilli. Purified O antigen induced no discernible protection, but some immunity was afforded by the administration of purified Vi antigen.

    Keywords:
    TYPHOID/immunology

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