Myxoid change in malignant lymphoma. Pathogenetic considerations

Area of Science:

• Oncology
• Pathology

Background:

• Myxoid change is an uncommon feature in malignant lymphoma.
• The underlying pathogenesis of myxoid change in lymphoma remains poorly understood.

Observation:

• A rare case of large B-cell lymphoma of the small bowel exhibited myxoid change.
• This myxoid change was localized to a regional lymph node involved by the lymphoma.

Findings:

• Vimentin-positive mesenchymal cells were increased in the myxoid zones of the lymph node.
• The tumor in other locations lacked myxoid change, suggesting localized factors are involved.

Implications:

• Local factors, potentially tissue edema, may stimulate fibroblast/myofibroblast proliferation.
• This contributes to the understanding of myxoid stroma formation in specific lymphoma cases.