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Prostate-specific antigen and prostate-specific acid phosphatase in neuroendocrine cells of prostate cancer
R J Cohen1, G Glezerson, Z Haffejee
1Department of Anatomical Pathology, School of Pathology, South African Institute for Medical Research, Johannesburg.
Archives of Pathology & Laboratory Medicine
|January 1, 1992
Abstract:
Prostate-specific antigen is a specific immunohistochemical marker of benign prostatic epithelium and prostate cancer. A subpopulation of neuroendocrine cells seen in 50% of cancers do not produce this protein marker. These cells appear to secrete prostate-specific acid phosphatase. This finding may explain the marked variation in serum prostate-specific antigen levels in all stages of prostate cancer.