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Increase in CD5+ B cells in juvenile rheumatoid arthritis. Relationship to IgM rheumatoid factor expression and
1Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI.
Objective:
To investigate the association between CD5+ B cell expression and IgM rheumatoid factor (IgM-RF) in juvenile rheumatoid arthritis (JRA).
Methods:
CD5+ B cell levels analyzed by flow cytometry and IgM-RF expression determined by enzyme-linked immunosorbent assay were compared in children with JRA, children with other collagen vascular diseases, and healthy controls.
Results:
Children with polyarticular JRA had expanded populations of CD5+ B cells, and expansion of CD5+ B cells and IgM-RF both correlated with disease activity.
Conclusion:
The results indicate that an expanded CD5+ B cell population leads to IgM-RF production in patients with polyarticular JRA, as well as patients with RA.