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The protective role of polyphenols in cytotoxicity of hydrogen peroxide
1Department of Food Science and Technology, Faculty of Agriculture, Nagoya University, Japan.
Mutation Research
|February 1, 1992
Abstract:
A variety of synthetic and natural polyphenols protect mammalian cells from hydrogen peroxide (H2O2). Cytotoxicity of H2O2 on Chinese hamster V79 cells was assessed with a colony formation assay, and several polyphenols prevented the decrease in the number of colonies caused by H2O2. A study of the structure-activity relationship revealed that affinity of the polyphenols for the cell membrane and the presence of an ortho-dihydroxy moiety in their structure proved essential to this protection.