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CpG methylated minichromosomes become inaccessible for V(D)J recombination after undergoing replication

C L Hsieh1, M R Lieber

  • 1Department of Pathology, Stanford University School of Medicine, CA 94305-5324.

The EMBO Journal
|January 1, 1992
PubMed
Summary

CpG methylation significantly hinders V(D)J recombination by creating a resistant chromatin structure after DNA replication. This epigenetic modification impacts antigen receptor accessibility and chromatin assembly during replication.

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