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Related Experiment Videos

Keratin expression in basal cell carcinomas.

A C Markey1, E B Lane, D M Macdonald

  • 1Laboratory of Applied Dermatology, UMDS, London.

The British Journal of Dermatology
|February 1, 1992
PubMed
Summary
This summary is machine-generated.

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Basal cell carcinomas (BCCs) show a distinct keratin profile, expressing keratins 5, 14, and 17, suggesting a follicular origin. This keratin expression pattern differs from typical skin differentiation markers.

Area of Science:

  • Dermatopathology
  • Molecular Biology
  • Cancer Research

Background:

  • Basal cell carcinoma (BCC) is the most common human cancer.
  • The cellular origin of BCC remains debated, with theories suggesting follicular or stem cell origins.
  • Keratin expression patterns are key indicators of cell differentiation and origin.

Purpose of the Study:

  • To investigate the keratin expression profile of basal cell carcinoma (BCC) tumors.
  • To compare the keratin phenotype of BCCs with normal epidermal and follicular keratinocytes.
  • To provide insights into the cellular origin of BCC based on keratin expression.

Main Methods:

  • Immunohistochemical analysis of 15 BCC tissue samples.
  • Utilized a panel of monospecific antibodies against various keratin polypeptides.

Related Experiment Videos

  • Examined expression of keratins 1, 5, 10, 14, 16, 17, 19, 8, and 18.

    • Main Results:

    • BCCs strongly expressed keratins 5 and 14 (basal keratinocyte markers).
    • No expression of keratins 1 and 10 (skin differentiation markers) was detected.
    • Strong expression of keratin 17 (outer hair root sheath marker) was observed in all tumors.
    • Keratin 16 (high cell turnover marker) was induced in overlying epidermis but rare in tumors.
    • No expression of simple epithelial keratins 8 and 18 was found.

    Conclusions:

    • The keratin profile of BCCs, particularly the expression of keratins 5, 14, and 17, supports a follicular origin.
    • Findings are also consistent with an origin from pluripotent stem cells differentiating towards follicular structures.
    • The distinct keratin phenotype differentiates BCCs from typical epidermal tumors.