Related Experiment Videos
Interaction of cholesterol-conjugated alkylating oligonucleotide derivatives with cellular biopolymers
A S Ryte1, V N Karamyshev, M V Nechaeva
1Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, Novosibirsk.
FEBS Letters
|March 9, 1992
Abstract:
Interactions of oligonucleotide derivatives with mammalian cells and cellular biopolymers have been investigated. The derivatives were oligonucleotides bearing an alkylating 2-chloroethylamino group at the 3'-end and a cholesterol residue at the 5'-terminal phosphate. These compounds are readily taken up by cells and react with cellular DNA, RNA and some proteins which may play a role in delivery of the compounds into cells.