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Characterization of two cDNAs encoding insulin-like growth factor 1 (IGF-1) in the human fetal brain
A C Sandberg-Nordqvist1, P A Ståhlbom, M Lake
1Karolinska Institute's Department of Pathology, Karolinska Hospital, Stockholm, Sweden.
Brain Research. Molecular Brain Research
|January 1, 1992
Abstract:
Insulin-like growth factor 1 (IGF-1) regulates growth of the brain. In order to characterize the variant IGF-1 present in human fetal brain we have determined the cDNA sequence for human fetal brain IGF-1. Using PCR to amplify cDNA obtained from isolated human fetal brain mRNA, two cDNA sequences encoding precursor proteins which correspond to IGF-1a and IGF-1b were obtained. This is the first characterisation of IGF-1 and its IGF-1a and IGF-1b precursors in the nervous system.