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Protactin, a new antibiotic metabolite and a possible precursor of the actinomycins
M Hanada1, K Sugawara, Y Nishiyama
1Bristol-Myers Squibb Research Institute, Tokyo, Japan.
The Journal of Antibiotics
|January 1, 1992
Abstract:
Streptomyces cucumerosporus strain L703-4 (ATCC 53784) produces a new 4-methyl-3-hydroxyanthraniloylpentapeptide lactone for which we have proposed the name protactin, in addition to several actinomycin components. Protactin is rather resistant to air oxidation but it can be converted to a new actinomycin, actinomycin Zp by ferricyanide oxidation. Actinomycin Zp possesses in vitro antibacterial activity and in vivo antitumor activity against P-388 leukemia in mice.