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Prostate specific antigen and prostatitis. II. PSA production and release kinetics in vitro
1Department of Urology, Tulane University School of Medicine, New Orleans, Louisiana.
The Prostate
|January 11, 1992
Summary
Elevated prostate specific antigen (PSA) in prostatitis is known, but mechanisms are unclear. This study found acute bacterial prostatitis does not increase PSA production or release stored PSA in cell models.
Area of Science:
- Urology
- Biochemistry
- Pathophysiology
Background:
- Elevated serum prostate specific antigen (PSA) is observed in patients with prostatitis.
- The underlying pathophysiological mechanisms for increased PSA in prostatitis remain poorly understood.
Purpose of the Study:
- To investigate the effect of prostatitis on PSA levels and production.
- To determine if prostatitis causes a release of sequestered PSA or affects PSA production kinetics.
Main Methods:
- Evaluated PSA levels in primates following prostatitis induction.
- Assessed PSA production by the LNCaP prostatic adenocarcinoma cell line when exposed to live and dead E. coli, bacterial supernatant, and complement.
Main Results:
- Primate studies showed a rapid rise and subsequent fall in PSA, suggesting release from a sequestered source.
- LNCaP cells produced PSA linearly; live E. coli caused cell sloughing and cessation of production after 4-8 hours, but did not induce stored PSA release.
- Dead bacteria, bacterial supernatant, and complement had no effect on PSA production.
Conclusions:
- The study indicates that acute bacterial prostatitis does not increase serum PSA levels through a storage release phenomenon.
- The observed increase in serum PSA during acute bacterial prostatitis is not explained by direct effects on PSA production or release from the LNCaP cell line model.
