Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Substance P: a late-acting B lymphocyte differentiation cofactor.

K L Bost1, D W Pascual

  • 1Department of Microbiology and Immunology, Tulane University Medical Center, New Orleans, Louisiana 70112.

The American Journal of Physiology
|March 1, 1992
PubMed
Summary

Substance P, a peptide, enhances immunoglobulin secretion in B lymphocytes, suggesting a key role in immune regulation. This peptide directly influences B cell antibody production, impacting immune responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Isolation of oxalotrophic bacteria associated with Varroa destructor mites.

Letters in applied microbiology·2015
Same author

Paratransgenesis feasibility in the honeybee (Apis mellifera) using Fructobacillus fructosus commensal.

Journal of applied microbiology·2014
Same author

M cell-targeted mucosal vaccine strategies.

Current topics in microbiology and immunology·2011
Same author

[Not Available].

The open microbiology journal·2009
Same author

Distal IgA immunity can be sustained by alphaEbeta7+ B cells in L-selectin-/- mice following oral immunization.

Mucosal immunology·2008
Same author

Tolerance in the absence of autoantigen.

Endocrine, metabolic & immune disorders drug targets·2007

Area of Science:

  • Immunology
  • Neuroscience
  • Cell Biology

Background:

  • Substance P is a neuropeptide with known effects on physiological processes.
  • Substance P receptors are present on leukocytes, indicating a potential role in immune regulation.
  • This review focuses on the impact of substance P on B lymphocytes.

Purpose of the Study:

  • To review the evidence for substance P's role in modulating B lymphocyte function.
  • To explore the direct effects of substance P on B cells and immunoglobulin secretion.

Main Methods:

  • In vivo studies in rodents involving increased substance P or its antagonists.
  • In vitro studies using cultures of purified B lymphocytes and B cell clones.
  • Radioreceptor binding assays and gene detection to identify substance P receptors.

Related Experiment Videos

Main Results:

  • Increased peripheral substance P levels in vivo correlate with increased immunoglobulin-secreting cells.
  • Substance P antagonists or depletion of substance P neurons reduce immunoglobulin synthesis.
  • Substance P enhances immunoglobulin secretion in activated B lymphocytes in vitro, acting directly on these cells.

Conclusions:

  • Substance P plays a significant role in regulating B lymphocyte function and immunoglobulin production.
  • B lymphocytes express functional substance P receptors, similar to those found on neurons.
  • Substance P directly modulates B cell antibody secretion, highlighting its immunomodulatory capacity.