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Marrow fibrosis associated with a Philadelphia chromosome
P C Nowell1, J A Kant, J B Finan
1Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia 19104-6082.
Cancer Genetics and Cytogenetics
|March 1, 1992
Abstract:
Three patients had marked marrow fibrosis and an apparent Philadelphia (Ph) chromosome. Hematologic, cytogenetic, and molecular studies demonstrated the heterogeneity of such cases, including the first example of clinically typical myelofibrosis (MF) associated with a bcr gene rearrangement characteristic of chronic myelogenous leukemia (CML).