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[Polyneuropathy in hyperthyroidism--a clinical neurophysiologic study].

P Berlit1, U Mahlberg, K H Usadel

  • 1Neurologische Klinik, Universität Heidelberg.

Schweizer Archiv Fur Neurologie Und Psychiatrie (Zurich, Switzerland : 1985)
|January 1, 1992
PubMed
Summary
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Hyperthyroidism can cause nerve and muscle issues, including weakness and sensory symptoms. Many patients show abnormal sensory nerve conduction, suggesting polyneuropathy linked to increased metabolism.

Area of Science:

  • Neurology
  • Endocrinology
  • Clinical Neurophysiology

Context:

  • Hyperthyroidism, a condition of excess thyroid hormone, can affect various bodily systems.
  • Neurological manifestations are reported in hyperthyroid patients, but comprehensive neurophysiological data are limited.

Purpose:

  • To investigate the neurophysiological profile of patients with hyperthyroidism.
  • To identify the prevalence of neuropathic and myopathic changes in this population.

Summary:

  • This prospective study assessed 27 hyperthyroid patients (mean age 56.4 years) for neurological symptoms and neurophysiological findings.
  • Muscle weakness and cramps were common complaints. Sensory nerve conduction velocities (NCV) of the sural nerve showed pathological or borderline findings in over 50% of patients.

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  • Electromyography revealed myopathic changes in some patients. No correlation was found between neurophysiological findings and thyroid hormone levels.

    • Impact:

    • Suggests that polyneuropathy is a common, potentially overlooked complication of hyperthyroidism.
    • Highlights the importance of neurophysiological evaluation in hyperthyroid patients experiencing neurological symptoms.
    • Underscores the role of hypermetabolism in the development of neuropathy associated with thyroid dysfunction.